An Extracellular MRI Polymeric Contrast Agent That Degrades at Physiological pH
نویسندگان
چکیده
منابع مشابه
An extracellular MRI polymeric contrast agent that degrades at physiological pH.
Macromolecular contrast agents have the potential to assist magnetic resonance imaging (MRI) due to their high relaxivity, but are not clinically useful because of toxicity due to poor clearance. We have prepared a biodegradable ketal-based polymer contrast agent which is designed to degrade rapidly at physiological pH by hydrolysis, facilitating renal clearance. In vitro, the agent degraded mo...
متن کاملA novel MRI contrast agent synthesized by ion exchange method
Objective: In this study, the zeolite-coated iron oxide nanoparticles were evaluated as MRI contrast agent and effect of the nanocomposite synthesis method on MRI contrast was tested. Materials and Methods: Ion exchange method was used for synthesis of iron oxide-zeolite and the as prepared nanocomposite was characterized by XRD, FESEM and TEM. The nanocomposite toxicity in the cell culture, a...
متن کاملHydrothermal Synthesis of an Ethiodol Based Ferrofluid as a Potential MRI Contrast Agent
In the present work, stable ferrofluids containing oleic acid capped magnetite nanoparticles were synthesized via low temperature hydrothermal method. The physical and chemical properties of the synthesized particles were studied using TEM, XRD, AFM, VSM and PCS techniques. Mean particles size of the samples was between 4.5 and 10 nanometers, depending on experimental conditions. Effect ...
متن کاملSxa2, a carboxypeptidase that degrades extracellular pheromone in fission yeast.
The fission yeast Schizosaccharomyces pombe exists in one of two mating types (Plus or Minus) and conjugation between two haploid cells is controlled by the reciprocal action of diffusible mating pheromones (for review, see 1). Thus, a P-cell releases P-factor and responds to M-factor since it expresses the M-factor receptor while an M-cell releases M-factor and responds to P-factor. Exposure t...
متن کامل[Utilization of polymeric micelle magnetic resonance imaging (MRI) contrast agent for theranostic system].
We applied a polymeric micelle carrier system for the targeting of a magnetic resonance imaging (MRI) contrast agent. Prepared polymeric micelle MRI contrast agent exhibited a long circulation characteristic in blood, and considerable amount of the contrast agent was found to accumulate in colon 26 solid tumor by the EPR effect. The signal intensities of tumor area showed 2-folds increase in T1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2012
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp2005998